the inhibitory effects of ascorbic acid, ?-tocopherol, and sodium selenite on proliferation of breast cancer cell lines

Authors

s shoaibi

g ludewige

mr oveisi

abstract

the role of antioxidants in prevention and treatment of cancers have been reported by several studies. in our investigation we studied the effects of ascorbic acid, ?-tocopherol, and sodium selenite on proliferation of two breast cancer cell lines: t47d (estrogen-receptor positive) and mda-mb-231 (estrogen-receptor negative). we also used 17-?-estradiol as positive control for proliferation of t47d cells. the viability of cells after 7 days of exposure to different concentrations of test compounds was determined by resazurine based method. ascorbic acid and ?-tocopherol significantly inhibited cell growth at a concentration of 10-4 m in both cell lines and antagonized the cell proliferation induced by 17-?-estradiol in t47d cells. sodium selenite at concentrations above 10-6m strongly inhibited the cell growth in both cell lines and suppressed the stimulated growth of t47d cells by 17-?-estradiol. our results with different strengths of activity of test compounds, further confirmed the findings of previous studies that showed the inhibitory effects of these antioxidants on other malignant cell lines.

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The Inhibitory Effects of Ascorbic Acid, ?-Tocopherol, and Sodium Selenite on Proliferation of Breast Cancer Cell Lines

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Journal title:
iranian journal of pharmaceutical research

جلد ۲۰۰۳، شماره ۷، صفحات ۱۷۳-۱۷۷

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